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KMID : 0043320120350030431
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Archives of Pharmacal Research
2012 Volume.35 No. 3 p.431 ~ p.436
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Biologically active C-alkylated flavonoids from Dodonaea viscosa
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Muhammad Akhtar
Anis Itrat
Khan Ajmal
Marasini Bishnu P.
Choudhary Muhammad Iqbal
Shah Muhammad Raza
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Abstract
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A new C-alkylated flavonoid (5,7-dihydroxy-3′-(4″-acetoxy-3″-methylbutyl)-3,6,4′-trimethoxyflavone (1), along with two known C-alkylated flavonoids (5,7-dihydroxy-3′-(3-hydroxymethylbutyl)-3,6,4′-trimethoxyflavone (2), 5,7,4′-trihydroxy-3′-(3-hyroxymethylbutyl)-3,6-dimethoxyflavone (3) and two new source C-alkylated flavonoids (5,7-dihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)-3,6,4′-trimethoxyflavone (4), 5,7,4′-trihydroxy-3,6-dimethoxy-3′-isoprenyl-flavone (5) were isolated from the aerial parts of Dodonaea viscosa. The structures of all compounds were established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The isolated compounds were evaluated for their inhibitory effect on urease and α-chymotrypsin enzyme. All the compounds (1?5) exhibited mild inhibition against urease but remained recessive in case of α-chymotrypsin.
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KEYWORD
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Dodonaea viscosa, Spindaceae, Flavonoid, Urease and α-chymotrypsin enzymes
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